Genome-wide association study identifies variations in 6p21.3 associated with nevirapine-induced rash.

doi:10.1093/cid/cir403

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Article

Genome-wide association study identifies variations in 6p21.3 associated with nevirapine-induced rash.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America - 1 Aug 2011

Chantarangsu Soranun, Mushiroda Taisei, Mahasirimongkol Surakameth, Kiertiburanakul Sasisopin, Sungkanuparph Somnuek, Manosuthi Weerawat, Tantisiriwat Woraphot, Charoenyingwattana Angkana, Sura Thanyachai, Takahashi Atsushi, Kubo Michiaki, Kamatani Naoyuki, Chantratita Wasun, Nakamura Yusuke

Abstract excerpt

BACKGROUND: We aimed to identify disease-predisposing variations with nevirapine-induced rash using genome-wide single-nucleotide polymorphisms (SNPs) as genetic markers. METHODS: A genome-wide association study (GWAS) was performed using ∼550000 markers in 72 human immunodeficiency virus (HIV)-infected Thai patients with nevirapine-induced rash and 77 nevirapine-tolerant patients, and then candidate SNPs were...

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PMID: 21810746
DOI: 10.1093/cid/cir403

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