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Article

Nevirapine-induced hepatotoxicity and pharmacogenetics: a retrospective study in a population from Mozambique.

Pharmacogenomics - 1 Jan 2010

Ciccacci Cinzia, Borgiani Paola, Ceffa Susanna, Sirianni Elisabetta, Marazzi Maria C, Altan Anna M Doro, Paturzo Giovanna, Bramanti Placido, Novelli Giuseppe, Palombi Leonardo

Abstract excerpt

AIMS: Nevirapine is widely used to treat HIV-1 infection to prevent mother-to-child transmission; unfortunately adverse drug reactions have been reported. Our aim was to identify genes/variants involved in nevirapine-induced hepatotoxicity. MATERIALS & METHODS: Patients from Mozambique, 78 with nevirapine-induced hepatotoxicity and 78 without adverse events, were genotyped for ABCB1, CYP2B6, CYP3A4 and CYP3A5...

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Source

Identifiers

PMID: 20017669
DOI: 10.2217/pgs.09.142

Genes

ABCB1

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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