Article
A genome-wide association study reveals association between common variants in an intergenic region of 4q25 and high-grade myopia in the Chinese Han population.
Human molecular genetics - 15 Jul 2011
Li Zhiqiang, Qu Jia, Xu Xun, Zhou Xiangtian, Zou Haidong, Wang Ning, Li Tao, Hu Xiaohan, Zhao Qian, Chen Peng, Li Wenjin, Huang Ke, Yang Jun, He Zangdong, Ji Jue, Wang Ti, Li Junyan, Li You, Liu Jie, Zeng Zhen, Feng Guoyin, He Lin, Shi Yongyong
Abstract excerpt
High-grade myopia (HM) is highly heritable, and has a high prevalence in the Han Chinese population. We carried out a genome-wide association study involving 102 HM cases suffering from retinal degeneration, and 335 controls who were free from HM and fundus diseases. Significant single-nucleotide polymorphisms were replicated in two follow-up studies: stage I involved 2628 independent cases and 9485 controls, and...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.