Article
Exome sequencing identifies ZNF644 mutations in high myopia.
PLoS genetics - 1 Jun 2011
Shi Yi, Li Yingrui, Zhang Dingding, Zhang Hao, Li Yuanfeng, Lu Fang, Liu Xiaoqi, He Fei, Gong Bo, Cai Li, Li Ruiqiang, Liao Shihuang, Ma Shi, Lin He, Cheng Jing, Zheng Hancheng, Shan Ying, Chen Bin, Hu Jianbin, Jin Xin, Zhao Peiquan, Chen Yiye, Zhang Yong, Lin Ying, Li Xi, Fan Yingchuan, Yang Huanming, Wang Jun, Yang Zhenglin
Abstract excerpt
Myopia is the most common ocular disorder worldwide, and high myopia in particular is one of the leading causes of blindness. Genetic factors play a critical role in the development of myopia, especially high myopia. Recently, the exome sequencing approach has been successfully used for the disease gene identification of Mendelian disorders. Here we show a successful application of exome sequencing to identify a...
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