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Article

The role of TWIST as a regulator in giant cell tumor of bone

18 Apr 2011

Abstract excerpt

Giant cell tumor of bone (GCT) is an aggressive tumor consisting of multinucleated osteoclast-like giant cells and proliferating osteoblast-like stromal cells. Our group has reported that the stromal cells express high levels of the bone resorbing matrix metalloproteinase (MMP)-13, and that this expression is regulated by the osteoblast transcription factor Runx2. The purpose of this study was to determine the...

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PMID: 21503964
DOI: 10.1002/jcb.23149

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