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Article

Epigenetic lockdown of CDKN1A (p21) and CDKN2A (p16) characterises the neoplastic spindle cell component of giant cell tumours of bone.

The Journal of pathology - 1 Aug 2022

Giesche Julian, Mellert Kevin, Geißler Sven, Arndt Sophia, Seeling Carolin, von Baer Alexandra, Schultheiss Markus, Marienfeld Ralf, Möller Peter, Barth Thomas Fe

Abstract excerpt

Giant cell tumour of bone (GCTB) comprises the eponymous osteoclastic multinucleated giant cells eliciting bone lysis, an H3F3A-mutated neoplastic mononucleated fibroblast-like cell population, and H3F3A wild-type mononucleated stromal cells. In this study, we characterised four new cell lines from GCTB. Furthermore, we compared the genome-wide DNA methylation profile of 13 such tumours and three further cell...

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PMID: 35522566
DOI: 10.1002/path.5925

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