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Article

TWIST, a basic helix-loop-helix transcription factor, can regulate the human osteogenic lineage

15 Dec 1999

Abstract excerpt

Basic helix-loop-helix (bHLH) transcription factors have been shown to play an important role in controlling cell type determination and differentiation. TWIST, a member of the bHLH transcription factor family, is involved in the development of mesodermally derived tissue, including the skeleton. We examined the role of human TWIST in osteoblast metabolism using stable expression of sense and antisense TWIST in...

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Identifiers

PMID: 10572240
DOI: 10.1002/(sici)1097-4644(19991215)75:4<566::aid-jcb3>3.0.co;2-0

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TWIST, a basic helix-loop-helix transcription factor, can regulate the human osteogenic lineagePMID 10572240Read ↗

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Twist Genes Regulate Runx2 and Bone FormationSemantic proximity Read ↗

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TWIST1 induces MMP3 expression through up-regulating DNA hydroxymethylation and promotes catabolic responses in human chondrocytesSemantic proximity Read ↗

Gene expression of TWIST1 and ZBTB16 is regulated by methylation modifications during the osteoblastic differentiation of mesenchymal stem cellsSemantic proximity Read ↗

Twist-related protein 1 negatively regulated osteoblastic transdifferentiation of human aortic valve interstitial cells by directly inhibiting runt-related transcription factor 2Semantic proximity Read ↗

Hypoxia-inducible factor-1alpha induces Twist expression in tubular epithelial cells subjected to hypoxia, leading to epithelial-to-mesenchymal transition.Semantic proximity Read ↗

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