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Article

Genome-Wide Transcriptome Profiling of the Neoplastic Giant Cell Tumor of Bone Stromal Cells by RNA Sequencing.

Journal of cellular biochemistry - 1 Jun 2017

Lau Carol P Y, Kwok Jamie S L, Tsui Joseph C C, Huang Lin, Yang Kevin Y, Tsui Stephen K W, Kumta Shekhar Madhukar

Abstract excerpt

Giant cell tumor of bone (GCTB) is the most common non-malignant primary bone tumor reported in Hong Kong. Failure of treatment in advanced GCTB with aggressive local recurrence remains a clinical challenge. In order to reveal the molecular mechanism underlying the pathogenesis of this tumor, we aimed to examine the transcriptome profiling of the neoplastic stromal cells of GCTB in this study. RNA-sequencing was...

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Source

Identifiers

PMID: 27862217
DOI: 10.1002/jcb.25792

Genes

SPP1
CSF1
MMP13
MSC
PLAUR
RUNX2
TSPAN12
VEGFA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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