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Aberrant paracrine signalling for bone remodelling underlies the mutant histone-driven giant cell tumour of bone

3 Aug 2022

Abstract excerpt

Abstract Oncohistones represent compelling evidence for a causative role of epigenetic perturbations in cancer. Giant cell tumours of bone (GCTs) are characterised by a mutated histone H3.3 as the sole genetic driver present in bone-forming osteoprogenitor cells but absent from abnormally large bone-resorbing osteoclasts which represent the hallmark of these neoplasms. While these striking features imply a...

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PMID: 36138226
DOI: 10.1038/s41418-022-01031-x

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