Article
Establishment and characterization of novel patient-derived cell lines from giant cell tumor of bone.
Human cell - 1 Nov 2021
Yoshimatsu Yuki, Noguchi Rei, Tsuchiya Ryuto, Ono Takuya, Sin Yooksil, Akane Sei, Sugaya Jun, Mori Tomoaki, Fukushima Suguru, Yoshida Akihiko, Kawai Akira, Kondo Tadashi
Abstract excerpt
Giant cell tumor of bone (GCTB) is a locally aggressive and rarely metastasizing tumor. GCTB is characterized by the presence of unique giant cells and a recurrent mutation in the histone tail of the histone variant H3.3, which is encoded by H3F3A on chromosome 1. GCTB accounts for ~ 5% of primary bone tumors. Although GCTB exhibits an indolent course, it has the potential to develop aggressive behaviors...
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