Article

Aberrant paracrine signalling for bone remodelling underlies the mutant histone-driven giant cell tumour of bone

2021-12-29

Abstract excerpt

Oncohistones represent compelling evidence for a causative role of epigenetic perturbations in cancer. Giant cell tumours of bone (GCTs) are characterised by a mutated histone H3.3 as the sole genetic driver present in bone-forming osteoprogenitor cells but absent from abnormally large bone-resorbing osteoclasts which represent the hallmark of these neoplasms. While these striking features imply a pathogenic inter...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 11e76cd5-19ea-56e3-a615-6b4c9c93fc6b
DOI: 10.1101/2021.12.27.474195

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Aberrant paracrine signalling for bone remodelling underlies the mutant histone-driven giant cell tumour of boneDOI 10.1101/2021.12.27.474195Read

Aberrant paracrine signalling for bone remodelling underlies the mutant histone-driven giant cell tumour of boneSemantic proximity Read

Drivers underpinning the malignant transformation of giant cell tumour of boneSemantic proximity Read

Histone H3.3 mutation in giant cell tumor of bone: an update in pathology.Semantic proximity Read

H3.3 G34W Promotes Growth and Impedes Differentiation of Osteoblast-Like Mesenchymal Progenitors in Giant Cell Tumor of BoneSemantic proximity Read

Giant cell tumor of bone: updated molecular pathogenesis and tumor biology.Semantic proximity Read

Diagnostic value of H3F3A mutations in giant cell tumour of bone compared to osteoclast‐rich mimicsSemantic proximity Read

Histone Deacetylase Inhibitors as a Therapeutic Strategy to Eliminate Neoplastic “Stromal” Cells from Giant Cell Tumors of BoneSemantic proximity Read

Epigenetic lockdown of CDKN1A (p21) and CDKN2A (p16) characterises the neoplastic spindle cell component of giant cell tumours of bone.Semantic proximity Read

Profiling of three H3F3A-mutated and denosumab-treated giant cell tumors of bone points to diverging pathways during progression and malignant transformation.Semantic proximity Read

Globally altered epigenetic landscape and lagging osteogenic differentiation in H3.3-G34W-mutant giant cell tumor of boneSemantic proximity Read

Mutation-driven epigenetic alterations as a defining hallmark of central cartilaginous tumours, giant cell tumour of bone and chondroblastoma.Semantic proximity Read

Globally altered epigenetic landscape and delayed osteogenic differentiation in H3.3-G34W-mutant giant cell tumor of boneSemantic proximity Read