Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Caspofungin dose escalation for invasive candidiasis due to resistant Candida albicans.

Antimicrobial agents and chemotherapy - 1 Jul 2011

Wiederhold Nathan P, Najvar Laura K, Bocanegra Rosie A, Kirkpatrick William R, Patterson Thomas F

Abstract excerpt

Previous in vivo studies have reported caspofungin dose escalation to be effective against Candida glabrata with reduced susceptibility. We hypothesized that higher doses of caspofungin would be effective against invasive candidiasis caused by the more virulent species Candida albicans, including isolates resistant to this echinocandin. Immunocompetent mice were inoculated with one of three C. albicans isolates,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antifungal Agents
Share to Candida albicans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Caspofungin

Share to Drug Resistance, Fungal

Share to Echinocandins

Share to Fungal Proteins

Share to Lipopeptides

Share to Mice, Inbred ICR

Source

Open in PubMed Open full text

Identifiers

PMID: 21502632
DOI: 10.1128/AAC.01750-10
PMCID: PMC3122388

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Caspofungin dose escalation for invasive candidiasis due to resistant Candida albicans.PMID 21502632Read ↗

The Gastrointestinal Tract Is a Major Source of Echinocandin Drug Resistance in a Murine Model of Candida glabrata Colonization and Systemic Dissemination.Semantic proximity Read ↗

Differential in vivo activities of anidulafungin, caspofungin, and micafungin against Candida glabrata isolates with and without FKS resistance mutations.Semantic proximity Read ↗

Disseminated Candidiasis caused by Candida albicans with amino acid substitutions in Fks1 at position Ser645 cannot be successfully treated with micafungin.Semantic proximity Read ↗

Clinical perspectives on echinocandin resistance among Candida species.Semantic proximity Read ↗

Echinocandin resistance in Candida species: mechanisms of reduced susceptibility and therapeutic approaches.Semantic proximity Read ↗

In vitro antifungal susceptibility of Candida glabrata to caspofungin and the presence of FKS mutations correlate with treatment response in an immunocompromised murine model of invasive infection.Semantic proximity Read ↗

Novel FKS mutations associated with echinocandin resistance in Candida species.Semantic proximity Read ↗

Elevated cell wall chitin in Candida albicans confers echinocandin resistance in vivo.Semantic proximity Read ↗

Candida glabrata mutants demonstrating paradoxical reduced caspofungin susceptibility but increased micafungin susceptibility.Semantic proximity Read ↗

Fks1 and Fks2 are functionally redundant but differentially regulated in Candida glabrata: implications for echinocandin resistance.Semantic proximity Read ↗

Fitness and virulence costs of Candida albicans FKS1 hot spot mutations associated with echinocandin resistance.Semantic proximity Read ↗

Optimizing Echinocandin dosing and susceptibility breakpoint determination via in vivo pharmacodynamic evaluation against Candida glabrata with and without fks mutations.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.