Article
Clinical perspectives on echinocandin resistance among Candida species.
Current opinion in infectious diseases - 1 Dec 2015
Shields Ryan K, Nguyen M Hong, Clancy Cornelius J
Abstract excerpt
PURPOSE OF REVIEW: We review and offer our clinical perspectives on the emergence of echinocandin-resistant Candida. RECENT FINDINGS: Candida FKS gene mutations attenuate echinocandin activity, but overall mutation rates among clinical isolates remain low (Candida glabrata, ∼4%; other species, <1%). Rates are higher with prior echinocandin exposure, exceeding 50% among C. glabrata or Candida albicans isolates...
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