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Novel FKS mutations associated with echinocandin resistance in Candida species.

Antimicrobial agents and chemotherapy - 1 May 2010

Garcia-Effron Guillermo, Chua Daniel Joseph, Tomada Jon Rupert, DiPersio Joseph, Perlin David S, Ghannoum Mahmoud, Bonilla Hector

Abstract excerpt

We studied three clinical isolates of Candida spp. (one C. tropicalis isolate and two C. glabrata isolates) from patients with invasive candidiasis. The first isolate emerged during echinocandin treatment, while the others emerged after the same treatment. These strains harbored an amino acid substitution in Fksp never linked before with reduced echinocandin susceptibility in C. tropicalis or in C. glabrata. The...

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Antifungal Agents
Candida glabrata
Candida tropicalis
Candidiasis
Drug Resistance, Fungal

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Glucosyltransferases

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PMID: 20145084
DOI: 10.1128/AAC.00998-09
PMCID: PMC2863628

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