Article
In vitro antifungal susceptibility of Candida glabrata to caspofungin and the presence of FKS mutations correlate with treatment response in an immunocompromised murine model of invasive infection.
Antimicrobial agents and chemotherapy - 1 Jul 2014
Fernández-Silva Fabiola, Lackner Michaela, Capilla Javier, Mayayo Emilio, Sutton Deanna, Castanheira Mariana, Fothergill Annette W, Lass-Flörl Cornelia, Guarro Josep
Abstract excerpt
It has been argued that the in vitro activity of caspofungin (CSP) is not a good predictor of the outcome of echinocandin treatment in vivo. We evaluated the in vitro activity of CSP and the presence of FKS mutations in the hot spot 1 (HS1) region of the FKS1 and FKS2 genes in 17 Candida glabrata...
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