Article
Elevated cell wall chitin in Candida albicans confers echinocandin resistance in vivo.
Antimicrobial agents and chemotherapy - 1 Jan 2012
Lee Keunsook K, Maccallum Donna M, Jacobsen Mette D, Walker Louise A, Odds Frank C, Gow Neil A R, Munro Carol A
Abstract excerpt
Candida albicans cells with increased cell wall chitin have reduced echinocandin susceptibility in vitro. The aim of this study was to investigate whether C. albicans cells with elevated chitin levels have reduced echinocandin susceptibility in vivo. BALB/c mice were infected with C. albicans cells with normal chitin levels and compared to mice infected with high-chitin cells. Caspofungin therapy was initiated at...
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