Article
Fks1 and Fks2 are functionally redundant but differentially regulated in Candida glabrata: implications for echinocandin resistance.
Antimicrobial agents and chemotherapy - 1 Dec 2012
Katiyar Santosh K, Alastruey-Izquierdo Ana, Healey Kelley R, Johnson Michael E, Perlin David S, Edlind Thomas D
Abstract excerpt
The echinocandins caspofungin, micafungin, and anidulafungin, inhibitors of cell wall β-1,3-glucan synthesis, were recently elevated to first-line agents for treating infections due to the azole-refractory yeast Candida glabrata. In Candida albicans, echinocandin resistance is strictly associated with mutations in Fks1, a large integral membrane protein and putative β-1,3-glucan synthase, while mutations in both...
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