Article
Disseminated Candidiasis caused by Candida albicans with amino acid substitutions in Fks1 at position Ser645 cannot be successfully treated with micafungin.
Antimicrobial agents and chemotherapy - 1 Jul 2011
Slater J L, Howard S J, Sharp A, Goodwin J, Gregson L M, Alastruey-Izquierdo A, Arendrup M C, Warn P A, Perlin D S, Hope W W
Abstract excerpt
The clinical utility of the echinocandins is potentially compromised by the emergence of drug resistance. We investigated whether Candida albicans with amino acid substitutions at position Ser645 in Fks1 can be treated with either a conventional or an elevated dosage of micafungin. We studied Candida albicans (wild-type SC5314; MIC, 0.06 mg/liter) and four fks1 mutants (one FKS1/fks1 heterozygote mutant [MIC, 0.5...
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