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Article

Fitness and virulence costs of Candida albicans FKS1 hot spot mutations associated with echinocandin resistance.

The Journal of infectious diseases - 15 Aug 2011

Ben-Ami Ronen, Garcia-Effron Guillermo, Lewis Russell E, Gamarra Soledad, Leventakos Konstantinos, Perlin David S, Kontoyiannis Dimitrios P

Abstract excerpt

The identification of FKS1 mutations in Candida albicans associated with echinocandin resistance has raised concerns over the spread of drug-resistant strains. We studied the impact of fks1 mutations on C. albicans virulence and fitness. Compared with wild-type strains for FKS1, echinocandin-resistant C. albicans strains with homozygous fks1 hot-spot mutations had reduced maximum catalytic capacity of their...

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Source

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Identifiers

PMID: 21791665
DOI: 10.1093/infdis/jir351
PMCID: PMC3144175

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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