Article
The Gastrointestinal Tract Is a Major Source of Echinocandin Drug Resistance in a Murine Model of Candida glabrata Colonization and Systemic Dissemination.
Antimicrobial agents and chemotherapy - 1 Dec 2017
Healey Kelley R, Nagasaki Yoji, Zimmerman Matthew, Kordalewska Milena, Park Steven, Zhao Yanan, Perlin David S
Abstract excerpt
Candida species are a part of the human microbiome and can cause systemic infection upon immune suppression. Candida glabrata infections are increasing and have greater rates of antifungal resistance than other species. Here, we present a C. glabrata gastrointestinal (GI) colonization model to explore whether colonized yeast exposed to caspofungin, an echinocandin antifungal, develop characteristic resistance...
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