Article
The glycosylphosphatidylinositol-linked aspartyl protease Yps1 is transcriptionally regulated by the calcineurin-Crz1 and Slt2 MAPK pathways in Candida glabrata.
FEMS yeast research - 1 Aug 2011
Miyazaki Taiga, Izumikawa Koichi, Yamauchi Shunsuke, Inamine Tatsuo, Nagayoshi Yohsuke, Saijo Tomomi, Seki Masafumi, Kakeya Hiroshi, Yamamoto Yoshihiro, Yanagihara Katsunori, Miyazaki Yoshitsugu, Yasuoka Akira, Kohno Shigeru
Abstract excerpt
In the pathogenic fungus Candida glabrata, the YPS1 gene, which encodes a glycosylphosphatidylinositol-linked aspartyl protease, is required for cell wall integrity and virulence. Although the expression of YPS1 has been studied in Saccharomyces cerevisiae, the transcriptional regulation of this gene in C. glabrata is not well understood. Here, we report that C. glabrata Yps1 is required for cell growth at...
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