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Article

Elucidation of the calcineurin-Crz1 stress response transcriptional network in the human fungal pathogen Cryptococcus neoformans.

PLoS genetics - 1 Apr 2017

Chow Eve W L, Clancey Shelly A, Billmyre R Blake, Averette Anna Floyd, Granek Joshua A, Mieczkowski Piotr, Cardenas Maria E, Heitman Joseph

Abstract excerpt

Calcineurin is a highly conserved Ca2+/calmodulin-dependent serine/threonine-specific protein phosphatase that orchestrates cellular Ca2+ signaling responses. In Cryptococcus neoformans, calcineurin is activated by multiple stresses including high temperature, and is essential for stress adaptation and virulence. The transcription factor Crz1 is a major calcineurin effector in Saccharomyces cerevisiae and other...

Topics

Calcineurin
Cell Wall
Cryptococcus neoformans
Fungal Proteins
Gene Expression Regulation, Fungal
Gene Regulatory Networks
Humans
Phenotype
Stress, Physiological
Transcription Factors

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Identifiers

PMID: 28376087
DOI: 10.1371/journal.pgen.1006667
PMCID: PMC5380312

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