Article
Cooperation between ER stress and calcineurin signaling contributes to the maintenance of cell wall integrity in Candida glabrata.
Fungal biology - 1 Jan 2018
Tanaka Yutaka, Sasaki Masato, Ito Fumie, Aoyama Toshio, Sato-Okamoto Michiyo, Takahashi-Nakaguchi Azusa, Chibana Hiroji, Shibata Nobuyuki
Abstract excerpt
Candida glabrata is the second most common source of Candida infections in humans. In this pathogen, the maintenance of cell wall integrity (CWI) frequently precludes effective pharmacological treatment by antifungal agents. In numerous fungi, cell wall modulation is reported to be controlled by endoplasmic reticulum (ER) stress, but how the latter affects CWI maintenance in C. glabrata is not clearly understood....
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