Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Overexpression of a dominant-negative allele of YPT1 inhibits growth and aspartyl protease secretion in Candida albicans.

Microbiology (Reading, England) - 1 Jul 2001

Lee Samuel A, Mao Yuxin, Zhang Zimei, Wong Brian

Abstract excerpt

To investigate the pre-Golgi secretion pathway in the pathogenic yeast Candida albicans, we cloned the C. albicans homologue of the Saccharomyces cerevisiae protein secretion gene YPT1. The C. albicans YPT1 ORF contained a 624 bp intronless ORF encoding a deduced protein of 207 aa and 2.3 kDa. This deduced protein was 77% identical to S. cerevisiae Ypt1 protein (Ypt1p) and it contained GTP-binding domains that...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aspartic Acid Endopeptidases
Share to Candida albicans

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Gene Deletion

Share to Gene Expression Regulation, Fungal

Share to Genes, Dominant

Share to Genes, Fungal

Share to rab GTP-Binding Proteins

Share to Saccharomyces cerevisiae Proteins

Source

Identifiers

PMID: 11429473
DOI: 10.1099/00221287-147-7-1961

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Overexpression of a dominant-negative allele of YPT1 inhibits growth and aspartyl protease secretion in Candida albicans.PMID 11429473Read ↗

Overexpression of a dominant-negative allele of SEC4 inhibits growth and protein secretion in Candida albicans.Semantic proximity Read ↗

The Ypt1 GTPase is essential for the first two steps of the yeast secretory pathway.Semantic proximity Read ↗

The glycosylphosphatidylinositol-linked aspartyl protease Yps1 is transcriptionally regulated by the calcineurin-Crz1 and Slt2 MAPK pathways in Candida glabrata.Semantic proximity Read ↗

Identification and structure of four yeast genes (SLY) that are able to suppress the functional loss of YPT1, a member of the RAS superfamily.Semantic proximity Read ↗

Divergence of Stp1 and Stp2 transcription factors in Candida albicans places virulence factors required for proper nutrient acquisition under amino acid control.Semantic proximity Read ↗

Functional analysis of Candida albicans genes whose Saccharomyces cerevisiae homologues are involved in endocytosis.Semantic proximity Read ↗

Tetracycline-inducible gene expression and gene deletion in Candida albicans.Semantic proximity Read ↗

Mutation of the Rab6 homologue of Saccharomyces cerevisiae, YPT6, inhibits both early Golgi function and ribosome biosynthesis.Semantic proximity Read ↗

LST1 is a SEC24 homologue used for selective export of the plasma membrane ATPase from the endoplasmic reticulum.Semantic proximity Read ↗

Blocking two-component signalling enhances Candida albicans virulence and reveals adaptive mechanisms that counteract sustained SAPK activation.Semantic proximity Read ↗

Single allele knock-out of Candida albicans CGT1 leads to unexpected resistance to hygromycin B and elevated temperature.Semantic proximity Read ↗

Establishing a role for the GTPase Ypt1p at the late Golgi.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.