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Article

Genomic and functional analyses unveil the response to hyphal wall stress in Candida albicans cells lacking β(1,3)-glucan remodeling.

BMC genomics - 2 Jul 2016

Degani Genny, Ragni Enrico, Botias Pedro, Ravasio Davide, Calderon Julia, Pianezzola Elena, Rodriguez-Peña Jose Manuel, Vanoni Maria Antonietta, Arroyo Javier, Fonzi William A, Popolo Laura

Abstract excerpt

BACKGROUND: The cell wall is essential for the yeast to hypha (Y-H) transition that enables Candida albicans to invade human tissues and evade the immune system. The main constituent, β(1,3)-glucan, is remodeled by glucanosyltransferases of the GH72 family. Phr1p is responsible of glucan remodeling at neutral-alkaline pH and is essential for morphogenesis and virulence. Due to the pH-regulated expression of PHR1,...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 27411447
DOI: 10.1186/s12864-016-2853-5
PMCID: PMC4942948

Genes

CCN1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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