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Aspartyl proteases in Candida glabrata are required for suppression of the host innate immune response

28 Feb 2018

Abstract excerpt

A family of 11 cell surface-associated aspartyl proteases (CgYps1–11), also referred as yapsins, is a key virulence factor in the pathogenic yeast Candida glabrata . However, the mechanism by which CgYapsins modulate immune response and facilitate survival in the mammalian host remains to be identified. Here, using RNA-Seq analysis, we report that genes involved in cell wall metabolism are differentially...

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PMID: 29491142
DOI: 10.1074/jbc.m117.813741

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