Article
TSPAN2 is involved in cell invasion and motility during lung cancer progression.
Cell reports - 24 Apr 2014
Otsubo Chihiro, Otomo Ryo, Miyazaki Makoto, Matsushima-Hibiya Yuko, Kohno Takashi, Iwakawa Reika, Takeshita Fumitaka, Okayama Hirokazu, Ichikawa Hitoshi, Saya Hideyuki, Kiyono Tohru, Ochiya Takahiro, Tashiro Fumio, Nakagama Hitoshi, Yokota Jun, Enari Masato
Abstract excerpt
In lung cancer progression, p53 mutations are more often observed in invasive tumors than in noninvasive tumors, suggesting that p53 is involved in tumor invasion and metastasis. To understand the nature of p53 function as a tumor suppressor, it is crucial to elucidate the detailed mechanism of the alteration in epithelial cells that follow oncogenic KRAS activation and p53 inactivation. Here, we report that KRAS...
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