Article
Single HA2 mutation increases the infectivity and immunogenicity of a live attenuated H5N1 intranasal influenza vaccine candidate lacking NS1.
PloS one - 7 Apr 2011
Krenn Brigitte M, Egorov Andrej, Romanovskaya-Romanko Ekaterina, Wolschek Markus, Nakowitsch Sabine, Ruthsatz Tanja, Kiefmann Bettina, Morokutti Alexander, Humer Johannes, Geiler Janina, Cinatl Jindrich, Michaelis Martin, Wressnigg Nina, Sturlan Sanda, Ferko Boris, Batishchev Oleg V, Indenbom Andrey V, Zhu Rong, Kastner Markus, Hinterdorfer Peter, Kiselev Oleg, Muster Thomas, Romanova Julia
Abstract excerpt
BACKGROUND: H5N1 influenza vaccines, including live intranasal, appear to be relatively less immunogenic compared to seasonal analogs. The main influenza virus surface glycoprotein hemagglutinin (HA) of highly pathogenic avian influenza viruses (HPAIV) was shown to be more susceptible to acidic pH treatment than that of human or low pathogenic avian influenza viruses. The acidification machinery of the human...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.