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Article

Identification, characterization, and natural selection of mutations driving airborne transmission of A/H5N1 virus.

Cell - 10 Apr 2014

Linster Martin, van Boheemen Sander, de Graaf Miranda, Schrauwen Eefje J A, Lexmond Pascal, Mänz Benjamin, Bestebroer Theo M, Baumann Jan, van Riel Debby, Rimmelzwaan Guus F, Osterhaus Albert D M E, Matrosovich Mikhail, Fouchier Ron A M, Herfst Sander

Abstract excerpt

Recently, A/H5N1 influenza viruses were shown to acquire airborne transmissibility between ferrets upon targeted mutagenesis and virus passage. The critical genetic changes in airborne A/Indonesia/5/05 were not yet identified. Here, five substitutions proved to be sufficient to determine this airborne transmission phenotype. Substitutions in PB1 and PB2 collectively caused enhanced transcription and virus...

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Share to Genome, Viral

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hemagglutinin Glycoproteins, Influenza Virus

Share to Influenza A Virus, H5N1 Subtype

Share to Influenza, Human

Share to Receptors, Virus

Share to RNA-Dependent RNA Polymerase

Share to Selection, Genetic

Source

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Identifiers

PMID: 24725402
DOI: 10.1016/j.cell.2014.02.040
PMCID: PMC4003409

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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