Article
Molecular requirements for a pandemic influenza virus: An acid-stable hemagglutinin protein.
Proceedings of the National Academy of Sciences of the United States of America - 9 Feb 2016
Russier Marion, Yang Guohua, Rehg Jerold E, Wong Sook-San, Mostafa Heba H, Fabrizio Thomas P, Barman Subrata, Krauss Scott, Webster Robert G, Webby Richard J, Russell Charles J
Abstract excerpt
Influenza pandemics require that a virus containing a hemagglutinin (HA) surface antigen previously unseen by a majority of the population becomes airborne-transmissible between humans. Although the HA protein is central to the emergence of a pandemic influenza virus, its required molecular properties for sustained transmission between humans are poorly defined. During virus entry, the HA protein binds receptors...
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