Article
Mutations affecting the stability of the haemagglutinin molecule impair the immunogenicity of live attenuated H3N2 intranasal influenza vaccine candidates lacking NS1.
Vaccine - 27 Apr 2011
Nakowitsch Sabine, Wolschek Markus, Morokutti Alexander, Ruthsatz Tanja, Krenn Brigitte M, Ferko Boris, Ferstl Nicole, Triendl Andrea, Muster Thomas, Egorov Andrej, Romanova Julia
Abstract excerpt
The isolation and cultivation of human influenza viruses in embryonated hen eggs or cell lines often leads to amino acid substitutions in the haemagglutinin (HA) molecule. We found that the propagation of influenza A H3N2 viruses on Vero cells may trigger the appearance of HA destabilising mutations, affecting viral resistance to low pH or high temperature treatment. Two ΔNS1 reassortants, containing the HA...
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