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Article

Cell-Culture Adaptation of H3N2 Influenza Virus Impacts Acid Stability and Reduces Airborne Transmission in Ferret Model.

Viruses - 21 Apr 2021

Le Sage Valerie, Kormuth Karen A, Nturibi Eric, Lee Juhye M, Frizzell Sheila A, Myerburg Michael M, Bloom Jesse D, Lakdawala Seema S

Abstract excerpt

Airborne transmission of seasonal and pandemic influenza viruses is the reason for their epidemiological success and public health burden in humans. Efficient airborne transmission of the H1N1 influenza virus relies on the receptor specificity and pH of fusion of the surface glycoprotein hemagglutinin (HA). In this study, we examined the role of HA pH of fusion on transmissibility of a cell-culture-adapted H3N2...

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Cell Culture Techniques
Ferrets
Hemagglutinin Glycoproteins, Influenza Virus
Hydrogen-Ion Concentration
Influenza A Virus, H3N2 Subtype

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Orthomyxoviridae Infections

Untranslated Regions

Virus Replication

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Identifiers

PMID: 33919124
DOI: 10.3390/v13050719
PMCID: PMC8143181

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