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Article

Effect of Acid-Stabilizing Hemagglutinin Mutations on Immunogenicity and Heterologous Protection by H1N1 Influenza Virus mRNA-LNP Vaccines.

Viruses - 15 Apr 2026

Ojha Chet R, Rovito Samuel W, Banoth Balaji, Kim Hyunsuh, Jones Jeremy C, Alameh Mohamad-Gabriel, Chen Po-Ling, Webby Richard J, Weissman Drew, Russell Charles J

Abstract excerpt

While current influenza vaccines often lack broad protection against antigenically drifted strains, some modified hemagglutinin (HA) protein antigens have shown promise in eliciting broadly neutralizing antibodies against conserved epitopes. During infection, the mildly acidic environment of the late endosome triggers irreversible HA conformational changes resulting in a post-fusion structure with altered...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hemagglutinin Glycoproteins, Influenza Virus

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Share to Influenza A Virus, H1N1 Subtype

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Source

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Identifiers

PMID: 42043256
DOI: 10.3390/v18040467
PMCID: PMC13119996

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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