Article

HA and M2 sequences alter the replication of 2013-16 H1 Live Attenuated Influenza Vaccine Infection in Human Nasal Epithelial Cell cultures

2021-11-12

Abstract excerpt

<h4>ABSTRACT</h4> From 2013-2016, the H1N1 component of live, attenuated influenza vaccine (LAIV) performed very poorly in contrast to the inactivated influenza vaccine. We utilized a primary, differentiated human nasal epithelial (hNEC) culture system to assess the replication differences between isogenic LAIVs containing the HA segment from either A/Bolivia/559/2013 (rBol), which showed poor vaccine efficacy, a...

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Literature Corpus work: 62cef193-0b12-5e0f-b397-b36a106f7bc4
DOI: 10.1101/2021.11.11.468304

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