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Article

Egg- or cell culture-derived hemagglutinin mutations impair virus stability and antigen content of inactivated influenza vaccines.

Biotechnology journal - 1 Mar 2014

Nakowitsch Sabine, Waltenberger Andrea M, Wressnigg Nina, Ferstl Nicole, Triendl Andrea, Kiefmann Bettina, Montomoli Emanuele, Lapini Giulia, Sergeeva Maria, Muster Thomas, Romanova Julia R

Abstract excerpt

Egg-derived viruses are the only available seed material for influenza vaccine production. Vaccine manufacturing is done in embryonated chicken eggs, MDCK or Vero cells. In order to contribute to efficient production of influenza vaccines, we investigate whether the quality of inactivated vaccines is influenced by the propagation substrate. We demonstrate that H3N2 egg-derived seed viruses (A/Brisbane/10/07,...

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Identifiers

PMID: 24323790
DOI: 10.1002/biot.201300225

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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