Article
A genome-wide linkage screen in the Amish with Parkinson disease points to chromosome 6.
Annals of human genetics - 1 May 2011
Cummings Anna C, Lee Stephen L, McCauley Jacob L, Jiang Lan, Crunk Amy, McFarland Lynne L, Gallins Paul J, Fuzzell Denise, Knebusch Clare, Jackson Charles E, Scott William K, Pericak-Vance Margaret A, Haines Jonathan L
Abstract excerpt
Parkinson disease (PD) is a common complex neurodegenerative disorder with an underlying genetic etiology that has been difficult to dissect. Although some PD risk genes have been discovered, most of the underlying genetic etiology remains unknown. To further elucidate the genetic component, we have undertaken a genome-wide linkage screen in an isolated founder population of Amish living in the Midwestern United...
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