Article
A genome-wide scan in an Amish pedigree with parkinsonism.
Annals of human genetics - 1 Sept 2008
Lee S L, Murdock D G, McCauley J L, Bradford Y, Crunk A, McFarland L, Jiang L, Wang T, Schnetz-Boutaud N, Haines J L
Abstract excerpt
The identification of familial Parkinson Disease (PD) genes is yielding important molecular pathogenetic insights. In an effort to identify additional PD genes, we studied an eight generation Amish pedigree with apparent autosomal dominant parkinsonism with incomplete penetrance. Phenotypic variability ranged from idiopathic PD to progressive supranuclear palsy (PSP), with the average age at onset 53 years (range...
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