Article
PARK6-linked parkinsonism occurs in several European families.
Annals of neurology - 1 Jan 2002
Valente Enza Maria, Brancati Francesco, Ferraris Alessandro, Graham Elizabeth A, Davis Mary B, Breteler Monique M B, Gasser Thomas, Bonifati Vincenzo, Bentivoglio Anna Rita, De Michele Giuseppe, Dürr Alexandra, Cortelli Pietro, Wassilowsky Dietmar, Harhangi Biswadjiet S, Rawal Nina, Caputo Viviana, Filla Alessandro, Meco Giuseppe, Oostra Ben A, Brice Alexis, Albanese Alberto, Dallapiccola Bruno, Wood Nicholas W
Abstract excerpt
The Parkin gene on 6q25.2-27 is responsible for about 50% of autosomal recessive juvenile parkinsonism and less than 20% of sporadic early-onset cases. We recently mapped a novel locus for early-onset parkinsonism (PARK6) on chromosome 1p35-p36 in a large family from Sicily. We now confirm linkage to PARK6 in eight additional families with Parkin-negative autosomal recessive juvenile parkinsonism from four...
Topics
- Adult
- Age of Onset
- Antiparkinson Agents
- Chromosomes, Human, Pair 1
- Europe
- Family Health
- Female
- Founder Effect
- Genetic Linkage