Article
PARK6 is a common cause of familial parkinsonism.
Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology - 1 Sept 2002
Valente E M, Brancati F, Caputo V, Graham E A, Davis M B, Ferraris A, Breteler M M B, Gasser T, Bonifati V, Bentivoglio A R, De Michele G, Dürr A, Cortelli P, Filla A, Meco G, Oostra B A, Brice A, Albanese A, Dallapiccola B, Wood N W
Abstract excerpt
The Parkin gene is responsible for about 50% of autosomal recessive juvenile parkinsonism (ARJP) and less than 20% of sporadic early onset cases. We recently mapped a novel ARJP locus (PARK6) on chromosome 1p. Linkage to PARK6 was confirmed in 8 families from 4 different European countries. These families share some clinical features with the European Parkin-positive cases, with a wide range of ages at onset and...
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