Genetic variation in DPP6 is associated with susceptibility to amyotrophic lateral sclerosis.

doi:10.1038/ng.2007.52

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Article

Genetic variation in DPP6 is associated with susceptibility to amyotrophic lateral sclerosis.

Nature genetics - 1 Jan 2008

van Es Michael A, van Vught Paul W J, Blauw Hylke M, Franke Lude, Saris Christiaan G J, Van den Bosch Ludo, de Jong Sonja W, de Jong Vianney, Baas Frank, van't Slot Ruben, Lemmens Robin, Schelhaas Helenius J, Birve Anna, Sleegers Kristel, Van Broeckhoven Christine, Schymick Jennifer C, Traynor Bryan J, Wokke John H J, Wijmenga Cisca, Robberecht Wim, Andersen Peter M, Veldink Jan H, Ophoff Roel A, van den Berg Leonard H

Abstract excerpt

We identified a SNP in the DPP6 gene that is consistently strongly associated with susceptibility to amyotrophic lateral sclerosis (ALS) in different populations of European ancestry, with an overall P value of 5.04 x 10(-8) in 1,767 cases and 1,916 healthy controls and with an odds ratio of 1.30 (95% confidence interval (CI) of 1.18-1.43). Our finding is the first report of a genome-wide significant association...

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PMID: 18084291
DOI: 10.1038/ng.2007.52

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DPP6

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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