Article
Autosomal recessive juvenile parkinsonism maps to 6q25.2-q27 in four ethnic groups: detailed genetic mapping of the linked region.
American journal of human genetics - 1 Jul 1998
Jones A C, Yamamura Y, Almasy L, Bohlega S, Elibol B, Hubble J, Kuzuhara S, Uchida M, Yanagi T, Weeks D E, Nygaard T G
Abstract excerpt
Parkinson disease (PD) is a common neurodegenerative condition associated with degeneration of dopaminergic neurons in the zona compacta of the substantia nigra. There is increasing evidence that genetic factors play a role in the etiology of PD, although genetic heterogeneity is likely. An autos...
Topics
- Age of Onset
- Alleles
- Chromosome Mapping
- Chromosomes, Human, Pair 6
- Consanguinity
- Female
- Genes, Recessive
- Genetic Linkage
- Humans
- Lod Score
- Male
- Parkinson Disease
- Pedigree
- Recombination, Genetic