Article
Localization of a novel locus for autosomal recessive early-onset parkinsonism, PARK6, on human chromosome 1p35-p36.
American journal of human genetics - 1 Apr 2001
Valente E M, Bentivoglio A R, Dixon P H, Ferraris A, Ialongo T, Frontali M, Albanese A, Wood N W
Abstract excerpt
The cause of Parkinson disease (PD) is still unknown, but genetic factors have recently been implicated in the etiology of the disease. So far, four loci responsible for autosomal dominant PD have been identified. Autosomal recessive juvenile parkinsonism (ARJP) is a clinically and genetically distinct entity; typical PD features are associated with early onset, sustained response to levodopa, and early...
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