Article
A susceptibility gene for late-onset idiopathic Parkinson's disease.
Annals of neurology - 1 Nov 2002
Hicks Andrew A, Pétursson Hjörvar, Jónsson Thorlákur, Stefánsson Hreinn, Jóhannsdóttir Hrefna S, Sainz Jesus, Frigge Michael L, Kong Augustine, Gulcher Jeffrey R, Stefánsson Kári, Sveinbjörnsdóttir Sigurlaug
Abstract excerpt
Eight regions of the genome (PARK1-8) have been implicated in autosomal dominant and autosomal recessive forms of early-onset Parkinson's disease. These forms constitute a few of all cases. However, except for a haplotype in six families (PARK3), no study has successfully mapped a gene or described mutations that contribute to the common late-onset Parkinson's disease. Some have even suggested that a genetic...
Topics
- Age of Onset
- Aged
- Alleles
- Chromosome Mapping
- Chromosomes, Human, Pair 1
- Female
- Genetic Linkage
- Genetic Predisposition to Disease
- Genome, Human
- Humans