Article
Genome-wide scan linkage analysis for Parkinson's disease: the European genetic study of Parkinson's disease.
Journal of medical genetics - 1 Dec 2004
Martinez M, Brice A, Vaughan J R, Zimprich A, Breteler M M B, Meco G, Filla A, Farrer M J, Bétard C, Hardy J, De Michele G, Bonifati V, Oostra B, Gasser T, Wood N W, Dürr A
Abstract excerpt
OBJECTIVE: To undertake a full genome-wide screen for Parkinson's disease susceptibility loci. METHODS: A genome-wide linkage study was undertaken in 227 affected sibling pairs from 199 pedigrees with Parkinson's disease. The pedigree sample consisted of 188 pedigrees from five European countries, and 11 from the USA. Individuals were genotyped for 391 microsatellite markers at approximately 10 cM intervals...
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