Article
Complete genomic screen in Parkinson disease: evidence for multiple genes.
JAMA - 14 Nov 2001
Scott W K, Nance M A, Watts R L, Hubble J P, Koller W C, Lyons K, Pahwa R, Stern M B, Colcher A, Hiner B C, Jankovic J, Ondo W G, Allen F H, Goetz C G, Small G W, Masterman D, Mastaglia F, Laing N G, Stajich J M, Slotterbeck B, Booze M W, Ribble R C, Rampersaud E, West S G, Gibson R A, Middleton L T, Roses A D, Haines J L, Scott B L, Vance J M, Pericak-Vance M A
Abstract excerpt
CONTEXT: The relative contribution of genes vs environment in idiopathic Parkinson disease (PD) is controversial. Although genetic studies have identified 2 genes in which mutations cause rare single-gene variants of PD and observational studies have suggested a genetic component, twin studies have suggested that little genetic contribution exists in the common forms of PD. OBJECTIVE: To identify genetic risk...
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