Article
Phenotype specific analyses reveal distinct regulatory mechanism for chronically activated p53.
PLoS genetics - 1 Mar 2015
Kirschner Kristina, Samarajiwa Shamith A, Cairns Jonathan M, Menon Suraj, Pérez-Mancera Pedro A, Tomimatsu Kosuke, Bermejo-Rodriguez Camino, Ito Yoko, Chandra Tamir, Narita Masako, Lyons Scott K, Lynch Andy G, Kimura Hiroshi, Ohbayashi Tetsuya, Tavaré Simon, Narita Masashi
Abstract excerpt
The downstream functions of the DNA binding tumor suppressor p53 vary depending on the cellular context, and persistent p53 activation has recently been implicated in tumor suppression and senescence. However, genome-wide information about p53-target gene regulation has been derived mostly from acute genotoxic conditions. Using ChIP-seq and expression data, we have found distinct p53 binding profiles between...
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