The NQO1*2/*2 polymorphism is associated with poor overall survival in patients following resection of stages II and IIIa non-small cell lung cancer.

doi:10.3892/or.2011.1249

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Article

The NQO12/2 polymorphism is associated with poor overall survival in patients following resection of stages II and IIIa non-small cell lung cancer.

Oncology reports - 1 Jun 2011

Kolesar Jill M, Dahlberg Suzanne E, Marsh Sharon, McLeod Howard L, Johnson David H, Keller Steven M, Schiller Joan H

Abstract excerpt

NAD(P)H:quinone oxidoreductase 1 (NQO1), is a cytosolic flavoenzyme that catalyzes the two-electron reduction of quinones into hydroquinones. A polymorphism (NQO1*2) alters enzymatic activity of NQO1 resulting in diminished NQO1 activity. Malignancies with NQO1*2 may be resistant to radiation and...

Topics

Antineoplastic Combined Chemotherapy Protocols
Biomarkers, Tumor
Carcinoma, Non-Small-Cell Lung
Cisplatin
Combined Modality Therapy
Etoposide
Female
Genotype
Humans
Kaplan-Meier Estimate
Lung Neoplasms
Male
NAD(P)H Dehydrogenase (Quinone)

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Neoplasm Staging

Polymorphism, Single Nucleotide

Proportional Hazards Models

Radiotherapy

Randomized Controlled Trials as Topic

Source

Open in PubMed Open full text

Identifiers

PMID: 21479364
DOI: 10.3892/or.2011.1249
PMCID: PMC3211091

Genes

NQO1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-21479364-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.