Article
NAD(P)H:quinone oxidoreductase 1 (NQO1) Pro187Ser polymorphism and the risk of lung, bladder, and colorectal cancers: a meta-analysis.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 May 2006
Chao Chun, Zhang Zuo-Feng, Berthiller Julien, Boffetta Paolo, Hashibe Mia
Abstract excerpt
UNLABELLED: NAD(P)H:quinone oxidoreductase 1 (NQO1) is a cytosolic enzyme that catalyzes the two-electron reduction of quinoid compounds into hydroquinones, their less toxic form. A sequence variant at position 609 (C --> T) in the NQO1 gene encodes an enzyme with reduced quinone reductase activi...
Topics
- Chi-Square Distribution
- Colorectal Neoplasms
- Genotype
- Humans
- Lung Neoplasms
- NAD(P)H Dehydrogenase (Quinone)
- Polymorphism, Genetic
- Smoking
- Urinary Bladder Neoplasms