Article
Evaluation of NQO1 gene expression and variant allele in human NSCLC tumors and matched normal lung tissue.
International journal of oncology - 1 Nov 2002
Kolesar Jill M, Pritchard Stuart C, Kerr Keith M, Kim Kyungman, Nicolson Marianne C, McLeod Howard
Abstract excerpt
NQO1 gene expression was evaluated by RT-PCR and SNP status by RFLP in matched samples of lung tumors and adjacent normal tissue. NQO1 was found to be overexpressed in lung tumors when compared to matched normal lung tissue. The mean expression in normal lung tissue was 28.26 x 10(-14) ng/microl +/- 44.9 SD and 61.46 x 10(-14) ng/microl +/- 103.2 SD in lung tumors. NQO1 gene expression was higher in the tumor...
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