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Article

Two minor NQO1 and NQO2 alleles predict poor response of breast cancer patients to adjuvant doxorubicin and cyclophosphamide therapy.

Pharmacogenetics and genomics - 1 Dec 2011

Jamieson David, Cresti Nicola, Bray Johanne, Sludden Julieann, Griffin Melanie J, Hawsawi Nahed M, Famie Eve, Mould Emily V A, Verrill Mark W, May Felicity E B, Boddy Alan V

Abstract excerpt

OBJECTIVE: A SNP in the NQO1 gene has been implicated in the response of patients with breast cancer to anthracycline containing regimens. NQO1, and its homologue NQO2, share many substrates yet retain distinct functional differences, with NQO2 being a more permissive molecule for electron accepting substrates. We aimed to determine whether functional NQO2 variants are associated with altered response to adjuvant...

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Source

Identifiers

PMID: 21946896
DOI: 10.1097/FPC.0b013e32834b6918

Genes

NQO2
NQO1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Two minor NQO1 and NQO2 alleles predict poor response of breast cancer patients to adjuvant doxorubicin and cyclophosphamide therapy.PMID 21946896Read ↗

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